Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC021
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-27 08:51
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/2 tbl PK Mertz a 100mg 1+2+0 tbl Yumex a 5mg jedna u 10h

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 22 individuals with a value less than 0.59 were subsequently diagnosed with PD. That is, 52.38% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.59 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 29, 'TN': 24, 'TP': 13, 'FP': 6}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 12, 'TP': 22, 'FP': 18}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.48
timePerCircleCoV 0.134767
timePerCircleSlope 0.0248258
meanError 1.4266
tremorFreq 6.93359
tremorRelPower 28.1451
tremorGyroAmpMean 0.029926
tremorGyroAmpSlope 0.000496386
tremorGyroAmpCoV 0.415328
tremorCoordAmpMean 0.0559701
tremorCoordAmpSlope 0.0013137
tremorCoordAmpCoV 0.351989
tremorAccAmpMean 0.0463046
tremorAccAmpSlope 0.00445164
tremorAccAmpCoV 0.402729
tremorPcRelVar 0.598068
tremorPcX -0.0163183
tremorPcY -0.999867

Circle Segment 1

Duration 6.88 s, Accuracy Estimate 1.521 (lower is better)

Circle Segment 2

Duration 6.72 s, Accuracy Estimate 1.515 (lower is better)

Circle Segment 3

Duration 8.04 s, Accuracy Estimate 1.403 (lower is better)

Circle Segment 4

Duration 5.68 s, Accuracy Estimate 1.63 (lower is better)

Circle Segment 5

Duration 6.48 s, Accuracy Estimate 1.3 (lower is better)

Circle Segment 6

Duration 8.48 s, Accuracy Estimate 1.222 (lower is better)

Circle Segment 7

Duration 7.64 s, Accuracy Estimate 1.146 (lower is better)

Circle Segment 8

Duration 8.8 s, Accuracy Estimate 1.081 (lower is better)

Circle Segment 9

Duration 8.4 s, Accuracy Estimate 1.252 (lower is better)

Circle Segment 10

Duration 7.68 s, Accuracy Estimate 2.195 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 30.876
timePerSpiralCoV 0.194712
timePerSpiralSlope 0.0127431
meanError 1.59925
tremorFreq 6.83594
tremorRelPower 26.9346
tremorGyroAmpMean 0.0337776
tremorGyroAmpSlope 0.00074502
tremorGyroAmpCoV 0.43437
tremorCoordAmpMean 0.0521223
tremorCoordAmpSlope 0.000221127
tremorCoordAmpCoV 0.362884
tremorAccAmpMean 0.0444688
tremorAccAmpSlope 0.000283404
tremorAccAmpCoV 0.333061
tremorPcRelVar 0.600668
tremorPcX 0.265611
tremorPcY -0.96408

Spiral Segment 1

Duration 28.84 s, Accuracy Estimate 1.714 (lower is better)

Spiral Segment 2

Duration 19.8 s, Accuracy Estimate 1.758 (lower is better)

Spiral Segment 3

Duration 28.24 s, Accuracy Estimate 1.613 (lower is better)

Spiral Segment 4

Duration 35.96 s, Accuracy Estimate 1.548 (lower is better)

Spiral Segment 5

Duration 38.48 s, Accuracy Estimate 1.497 (lower is better)

Spiral Segment 6

Duration 31.52 s, Accuracy Estimate 1.437 (lower is better)

Spiral Segment 7

Duration 37.68 s, Accuracy Estimate 1.52 (lower is better)

Spiral Segment 8

Duration 29.8 s, Accuracy Estimate 1.589 (lower is better)

Spiral Segment 9

Duration 34.44 s, Accuracy Estimate 1.518 (lower is better)

Spiral Segment 10

Duration 24.0 s, Accuracy Estimate 1.798 (lower is better)

Elel

eDurationMean 0.628846
eDurationStd 0.131767
eDurationStdnorm 0.209537
eDurationMedian 0.6
eDurationQuartdelta 0.19625
eDurationQuartdeltanorm 0.327083
eDurationKurt 2.4398
eDurationTrenddiff 0.08
eDurationTrendratio 1.13333
eWidthMean 6.417
eWidthStd 1.50876
eWidthStdnorm 0.23512
eWidthMedian 6.201
eWidthQuartdelta 1.638
eWidthQuartdeltanorm 0.264151
eWidthKurt 3.2286
eWidthTrenddiff -0.819
eWidthTrendratio 0.875
eHeightMean 11.967
eHeightStd 1.88006
eHeightStdnorm 0.157103
eHeightMedian 12.168
eHeightQuartdelta 2.89575
eHeightQuartdeltanorm 0.237981
eHeightKurt 2.19144
eHeightTrenddiff 0.117
eHeightTrendratio 1.00971
eAspectMean 0.536491
eAspectStd 0.0946876
eAspectStdnorm 0.176494
eAspectMedian 0.528736
eAspectQuartdelta 0.115166
eAspectQuartdeltanorm 0.217814
eAspectKurt 2.83225
eAspectTrenddiff -0.0473684
eAspectTrendratio 0.913462
eSlantMean 0.0699436
eSlantStd 0.0971511
eSlantStdnorm 1.38899
eSlantMedian 0.0632911
eSlantQuartdelta 0.111356
eSlantQuartdeltanorm 1.75943
eSlantKurt 3.23688
eSlantTrenddiff 0.0106596
eRtopMean 0.73641
eRtopStd 0.108189
eRtopStdnorm 0.146914
eRtopMedian 0.734694
eRtopQuartdelta 0.123747
eRtopQuartdeltanorm 0.168433
eRtopKurt 4.11598
eRtopTrenddiff 0.0112896
eRbotMean 0.611282
eRbotStd 0.114491
eRbotStdnorm 0.187297
eRbotMedian 0.608696
eRbotQuartdelta 0.169612
eRbotQuartdeltanorm 0.278648
eRbotKurt 2.49287
eRbotTrenddiff -0.00832562
eRrightMean 0.856089
eRrightStd 0.0659451
eRrightStdnorm 0.0770306
eRrightMedian 0.875
eRrightQuartdelta 0.0873273
eRrightQuartdeltanorm 0.0998027
eRrightKurt 2.88515
eRrightTrenddiff 0.0232323
eRleftMean 0.36283
eRleftStd 0.0811533
eRleftStdnorm 0.223668
eRleftMedian 0.351351
eRleftQuartdelta 0.106616
eRleftQuartdeltanorm 0.303446
eRleftKurt 2.66801
eRleftTrenddiff -0.019019
lDurationMean 0.79525
lDurationStd 0.127138
lDurationStdnorm 0.159872
lDurationMedian 0.775
lDurationQuartdelta 0.155
lDurationQuartdeltanorm 0.2
lDurationKurt 3.23681
lDurationTrenddiff 0.055
lDurationTrendratio 1.07358
lWidthMean 9.71393
lWidthStd 1.80974
lWidthStdnorm 0.186304
lWidthMedian 9.594
lWidthQuartdelta 2.5155
lWidthQuartdeltanorm 0.262195
lWidthKurt 2.85086
lWidthTrenddiff -1.2285
lWidthTrendratio 0.880682
lHeightMean 24.9912
lHeightStd 2.44315
lHeightStdnorm 0.0977603
lHeightMedian 24.687
lHeightQuartdelta 2.8665
lHeightQuartdeltanorm 0.116114
lHeightKurt 2.99758
lHeightTrenddiff -2.34
lHeightTrendratio 0.910714
lAspectMean 0.388016
lAspectStd 0.0579251
lAspectStdnorm 0.149285
lAspectMedian 0.391328
lAspectQuartdelta 0.0745884
lAspectQuartdeltanorm 0.190603
lAspectKurt 3.59918
lAspectTrenddiff -0.00636735
lAspectTrendratio 0.983834
lSlantMean 0.164537
lSlantStd 0.0811801
lSlantStdnorm 0.493386
lSlantMedian 0.17575
lSlantQuartdelta 0.0796258
lSlantQuartdeltanorm 0.453064
lSlantKurt 3.85323
lSlantTrenddiff 0.020086
lRtopMean 0.857221
lRtopStd 0.068599
lRtopStdnorm 0.0800249
lRtopMedian 0.869963
lRtopQuartdelta 0.0842104
lRtopQuartdeltanorm 0.0967977
lRtopKurt 6.8021
lRtopTrenddiff 0.0303486
lRbotMean 0.44876
lRbotStd 0.142393
lRbotStdnorm 0.317302
lRbotMedian 0.413082
lRbotQuartdelta 0.178808
lRbotQuartdeltanorm 0.432862
lRbotKurt 3.28316
lRbotTrenddiff -0.0131035
lRrightMean 0.918031
lRrightStd 0.0458773
lRrightStdnorm 0.0499736
lRrightMedian 0.924739
lRrightQuartdelta 0.0625337
lRrightQuartdeltanorm 0.067623
lRrightKurt 4.8521
lRrightTrenddiff 0.000716187
lRleftMean 0.218911
lRleftStd 0.0695368
lRleftStdnorm 0.317649
lRleftMedian 0.205075
lRleftQuartdelta 0.0872115
lRleftQuartdeltanorm 0.425267
lRleftKurt 3.58229
lRleftTrenddiff 0.00306195

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.806196
sumTouchScores 16.1239
meanMovementTime 0.855
numTouches 20
undershootPercentage 0
overshootPercentage 30

FITTS Long Modified

meanTouchScore 0.89193
sumTouchScores 12.487
meanMovementTime 1.31308
numTouches 14
undershootPercentage 7.14286
overshootPercentage 7.14286

ZigZag

numZigzags 5
timePerZigzagMean 33.712
timePerZigzagCoV 0.255043
timePerZigzagSlope 0.14879
meanError 1.94608
tremorFreq 6.15234
tremorRelPower 27.353
tremorGyroAmpMean 0.0360054
tremorGyroAmpSlope -0.00223652
tremorGyroAmpCoV 0.396177
tremorCoordAmpMean 0.060425
tremorCoordAmpSlope -0.00244655
tremorCoordAmpCoV 0.366013
tremorAccAmpMean 0.0920825
tremorAccAmpSlope -0.00143718
tremorAccAmpCoV 0.203764
tremorPcRelVar 0.742551
tremorPcX -0.403482
tremorPcY -0.914987

ZigZag Segment 1

Duration 19.76 s, Accuracy Estimate 2.214 (lower is better)

ZigZag Segment 2

Duration 33.36 s, Accuracy Estimate 1.711 (lower is better)

ZigZag Segment 3

Duration 33.88 s, Accuracy Estimate 1.914 (lower is better)

ZigZag Segment 4

Duration 40.08 s, Accuracy Estimate 1.831 (lower is better)

ZigZag Segment 5

Duration 41.48 s, Accuracy Estimate 2.061 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 16.48
timePerZigzagCoV 0.0735201
timePerZigzagSlope 0.0194175
zigzagHeightMean 52.8664
zigzagHeightCoV 0.0711811
zigzagHeightSlope -0.0424385
meanError 0.03098
tremorFreq 6.54297
tremorRelPower 31.1685
tremorGyroAmpMean 0.0476467
tremorGyroAmpSlope -0.00238719
tremorGyroAmpCoV 0.337345
tremorCoordAmpMean 0.0769642
tremorCoordAmpSlope -0.00332685
tremorCoordAmpCoV 0.288974
tremorAccAmpMean 0.0708414
tremorAccAmpSlope -0.00480731
tremorAccAmpCoV 0.301601
tremorPcRelVar 0.653668
tremorPcX -0.305747
tremorPcY -0.952113

ZigZag Offset Segment 1

Duration 14.84 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 2

Duration 17.84 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 3

Duration 16.44 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 4

Duration 15.84 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 5

Duration 17.44 s, Accuracy Estimate 0.034 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.59}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.49886819434348517}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.2861265611495569}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}